Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12203995 | 0.98 | KDM4E (0.51) | KDM4EALDH1A1TDP1MAPTHTT | |
| SCHEMBL11329325 | 0.86 | ALDH1A1 (0.62) | KDM4EALDH1A1TDP1MAPTHTT | |
| SCHEMBL21127873 | 0.83 | KDM4E (0.67) | KDM4EALDH1A1TDP1L3MBTL1KMT2A | |
| SCHEMBL13828361 | 0.83 | HTT (0.51) | KDM4EALDH1A1TDP1MAPTHTT | |
| SCHEMBL14625789 | 0.80 | ALDH1A1 (0.54) | KDM4EALDH1A1TDP1KMT2AMEN1 | |
| SCHEMBL15084308 | 0.79 | LMNA (0.51) | KDM4EALDH1A1KMT2AMEN1MAPK1 | |
| SCHEMBL13185587 | 0.78 | ALDH1A1 (0.51) | KDM4EALDH1A1TDP1MAPTHTT | |
| SCHEMBL13375730 | 0.78 | KDM4E (0.44) | KDM4EALDH1A1TDP1KMT2AMEN1 | |
| SCHEMBL807388 | 0.77 | LMNA (0.50) | KDM4EALDH1A1KMT2AMEN1MAPK1 | |
| SCHEMBL1474097 | 0.77 | KDM4E (0.69) | KDM4EALDH1A1TDP1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008118724-A1 | INDOLE CARBOXAMIDES AS IKK2 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-02 | — | — | WO | disclosed |