Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15084308 | 0.84 | LMNA (0.51) | LMNAKMT2ARAB9APOLBGAA | |
| SCHEMBL15081948 | 0.80 | KMT2A (0.49) | LMNAKMT2ARAB9APOLBGAA | |
| SCHEMBL12203995 | 0.79 | KDM4E (0.51) | LMNAKMT2ARAB9APOLBGAA | |
| SCHEMBL22946992 | 0.79 | KMT2A (0.47) | LMNAKMT2ARAB9APOLBGAA | |
| SCHEMBL14049765 | 0.77 | KDM4E (0.54) | LMNAKMT2ARAB9APOLBGAA | |
| SCHEMBL21127876 | 0.76 | POLB (0.51) | LMNAKMT2ARAB9APOLBGAA | |
| SCHEMBL82397 | 0.74 | HRH3 (0.53) | LMNAPOLBALDH1A1HRH3 | |
| SCHEMBL14625789 | 0.73 | ALDH1A1 (0.54) | LMNAKMT2ARAB9APOLBGAA | |
| SCHEMBL6371390 | 0.73 | CDC7 (0.41) | LMNAKMT2APOLBGAAKDM4E | |
| SCHEMBL807393 | 0.73 | ALDH1A1 (0.43) | KMT2APOLBKDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012036997-A1 | FUSED PYRAZOLE DERIVATIVES AS NOVEL ERK INHIBITORS | SCHERING CORPORATION (US) | 2012-03-22 | — | — | WO | disclosed |