Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA6 | P23280 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 2/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12519534 | 0.81 | ALDH1A1 (0.47) | ALDH1A1KDRKDM4ELMNASMN1; SMN2 | |
| SCHEMBL24512696 | 0.81 | ALDH1A1 (0.46) | SOS1ALDH1A1KDRKDM4ELMNA | |
| SCHEMBL1137172 | 0.80 | NOS3 (0.50) | NR4A1SOS1MAPK14ALDH1A1MET | |
| SCHEMBL29834758 | 0.77 | NR4A1 (0.41) | NR4A1SOS1MAPK14ALDH1A1CA12 | |
| SCHEMBL573471 | 0.77 | NR4A1 (0.41) | NR4A1SOS1MAPK14ALDH1A1MAP4K4 | |
| SCHEMBL1410166 | 0.77 | GRM2 (0.42) | NR4A1SOS1MAPK14ALDH1A1MAP4K4 | |
| SCHEMBL29834775 | 0.77 | NR4A1 (0.41) | NR4A1SOS1MAPK14ALDH1A1MAP4K4 | |
| Formamide SCHEMBL28986166 | 0.77 | KDR (0.41) | MAPK14ALDH1A1KDRKDM4ESMN1; SMN2 | |
| SCHEMBL863328 | 0.77 | NR4A1 (0.61) | NR4A1SOS1ALDH1A1CA12CA1 | |
| SCHEMBL23637719 | 0.76 | NR4A1 (0.47) | NR4A1SOS1MAPK14ALDH1A1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080269267-A1 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFIC DISEASES AND OTHER PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269267-A1 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFIC DISEASES AND OTHER PROLIFERATIVE DISEASES | BRAF, RET, KIT | NR4A1 2643/4885SOS1 2356/4885MAPK14 281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.