Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14052544 | 0.87 | SMN1; SMN2 (0.50) | MEN1KMT2AHPGDALDH1A1MAPT | |
| SCHEMBL14052375 | 0.87 | RECQL (0.44) | MEN1KMT2AHPGDALDH1A1MAPT | |
| SCHEMBL14052487 | 0.86 | HPGD (0.53) | MEN1KMT2AHPGDALDH1A1MAPT | |
| SCHEMBL14052531 | 0.85 | MAPT (0.39) | MEN1KMT2AHPGDALDH1A1MAPT | |
| SCHEMBL14052453 | 0.85 | ALDH1A1 (0.39) | MEN1KMT2AHPGDALDH1A1MAPT | |
| SCHEMBL14052326 | 0.84 | HPGD (0.51) | MEN1KMT2AHPGDALDH1A1MAPT | |
| SCHEMBL14052466 | 0.83 | TRPV1 (0.42) | MEN1KMT2AHPGDALDH1A1MAPT | |
| SCHEMBL14134406 | 0.81 | MEN1 (0.38) | MEN1KMT2AHPGDALDH1A1MAPT | |
| SCHEMBL14052790 | 0.79 | MEN1 (0.37) | MEN1KMT2AHPGDALDH1A1MAPT | |
| SCHEMBL14052389 | 0.79 | HSP90AA1 (0.38) | MEN1KMT2AHPGDALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150166500-A1 | Compounds and Methods for Catalytic Directed ortho Substitution of Aromatic Amides and Esters | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2015-06-18 | — | — | US | disclosed |
| US-20150166500-A1 | Compounds and Methods for Catalytic Directed ortho Substitution of Aromatic Amides and Esters | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2015-06-18 | — | — | US | disclosed |
| US-20120302752-A1 | Compounds and Methods for Catalytic Directed ortho Substitution of Aromatic Amides and Esters | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2012-11-29 | — | — | US | disclosed |
| US-20120302752-A1 | Compounds and Methods for Catalytic Directed ortho Substitution of Aromatic Amides and Esters | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2012-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150166500-A1 | Compounds and Methods for Catalytic Directed ortho Substitution of Aromatic Amides and Esters | DDC, AOC2, AOC3 | MEN1 4327/4885KMT2A 1382/4885HPGD 2168/4885 |
| US-20120302752-A1 | Compounds and Methods for Catalytic Directed ortho Substitution of Aromatic Amides and Esters | DDC, AOC2, AOC3 | MEN1 4327/4885KMT2A 1382/4885HPGD 2168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.