Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.44 |
| ▸ | RAF1 | P04049 | 3/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21411362 | 0.85 | ALDH1A1 (0.58) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL612156 | 0.83 | MAPT (0.42) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL490588 | 0.83 | IKBKB (0.57) | IKBKB | |
| SCHEMBL5463033 | 0.82 | MAPK14 (0.48) | MAPTKDM4EALDH1A1LMNAIKBKB | |
| SCHEMBL16267991 | 0.81 | IKBKB (0.61) | ALDH1A1IKBKBHPGDMAPK14RAF1 | |
| SCHEMBL612016 | 0.80 | MAPK14 (0.41) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL26189260 | 0.80 | RAF1 (0.41) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL101455 | 0.79 | RAF1 (0.42) | MAPTKDM4EALDH1A1LMNAMAPK14 | |
| SCHEMBL27192028 | 0.79 | ALDH1A1 (0.54) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL669321 | 0.77 | RAF1 (0.39) | MAPTKDM4EALDH1A1LMNAIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025262243-A1 | THIENO- AND THIAZOLOPYRIMIDINE-2,6-DIONES AND USE THEREOF AS IMMUNOMODULATORS | INVIOS GMBH (AT) | 2025-12-26 | — | — | WO | disclosed |
| US-20250009723-A1 | MANNOSE-DERIVED ANTAGONISTS OF FIMH USEFUL FOR TREATING DISEASE | FIMBRION THERAPEUTICS, INC. | 2025-01-09 | — | — | US | disclosed |
| EP-3003322-B1 | MANNOSE DERIVATIVES AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS | WASHINGTON UNIVERSITY ST LOUIS (US) | 2023-09-13 | — | — | EP | disclosed |
| EP-3003322-B1 | MANNOSE DERIVATIVES AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS | WASHINGTON UNIVERSITY ST LOUIS (US) | 2023-09-13 | — | — | EP | disclosed |
| WO-2023056951-A1 | ARYL-SUBSTITUTED HETEROCYCLIC COMPOUND | 杭州德睿智药科技有限公司 | 2023-04-13 | — | — | WO | disclosed |
| US-20230033327-A1 | COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS | WASHINGTON UNIVERSITY | 2023-02-02 | — | — | US | disclosed |
| US-20220235087-A1 | MANNOSE-DERIVED ANTAGONISTS OF FIMH USEFUL FOR TREATING DISEASE | FIMBRION THERAPEUTICS, INC. | 2022-07-28 | — | — | US | disclosed |
| US-20210122776-A1 | COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2021-04-29 | — | — | US | disclosed |
| US-20200407390-A1 | MANNOSE-DERIVED ANTAGONISTS OF FIMH USEFUL FOR TREATING DISEASE | FIMBRION THERAPEUTICS INC (US) | 2020-12-31 | — | — | US | disclosed |
| US-10738070-B2 | Mannose-derived antagonists of FimH useful for treating disease | FIMBRION THERAPEUTICS, INC. (US) | 2020-08-11 | — | — | US | disclosed |
| WO-2014194270-A1 | COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS | WASHINGTON UNIVERSITY (US) | 2014-12-04 | — | — | WO | disclosed |
| US-20120309701-A1 | COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS | THE WASHINGTON UNIVERSITY (US) | 2012-12-06 | — | — | US | disclosed |
| US-20120309701-A1 | COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS | THE WASHINGTON UNIVERSITY (US) | 2012-12-06 | — | — | US | disclosed |
| EP-2305671-A1 | Thiophene and thiazole derivatives as CHK1 inhibitors | AstraZeneca AB (SE) | 2011-04-06 | — | — | EP | disclosed |
| EP-1732920-B1 | THIOPHENE DERIVATIVES AS CHK 1 INHIBITORS | ASTRAZENECA AB (SE) | 2011-03-09 | — | — | EP | disclosed |
| CN-100584840-C | Substituted heterocyclic compounds and uses thereof | ASTRAZENECA AB | 2010-01-27 | — | — | CN | disclosed |
| CN-1922172-A | Substituted heterocyclic compounds and uses thereof | ASTRAZENECA AB (SE) | 2007-02-28 | — | — | CN | disclosed |
| US-20070010556-A1 | Thiophene derivatives as chk 1 inhibitors | ASTRAZENECA AB (SE) | 2007-01-11 | — | — | US | disclosed |
| EP-1732920-A2 | THIOPHENE DERIVATIVES AS CHK 1 INHIBITORS | AstraZeneca AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005066163-A2 | THIOPHENE DERIVATIVES AS CHK 1 INIHIBITORS | ASTRAZENECA AB (SE) | 2005-07-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230033327-A1 | COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS | FPR1, VIL1, VIP | MAPT 955/4885KDM4E 4317/4885ALDH1A1 526/4885 |
| US-20250009723-A1 | MANNOSE-DERIVED ANTAGONISTS OF FIMH USEFUL FOR TREATING DISEASE | MAN2B2, MAN2A1, MANBA | MAPT 2578/4885KDM4E 4648/4885ALDH1A1 1880/4885 |
| US-20120309701-A1 | COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS | MMP8, ELANE, GUSB | MAPT 2205/4885KDM4E 3809/4885ALDH1A1 519/4885 |
| US-20200407390-A1 | MANNOSE-DERIVED ANTAGONISTS OF FIMH USEFUL FOR TREATING DISEASE | MAN2B2, MAN2A1, MANBA | MAPT 2578/4885KDM4E 4648/4885ALDH1A1 1880/4885 |
| US-20070010556-A1 | Thiophene derivatives as chk 1 inhibitors | CHEK1, CHKA, CHEK2 | MAPT 3514/4885KDM4E 713/4885ALDH1A1 2326/4885 |
| US-20220235087-A1 | MANNOSE-DERIVED ANTAGONISTS OF FIMH USEFUL FOR TREATING DISEASE | MAN2B2, MAN2A1, MANBA | MAPT 2578/4885KDM4E 4648/4885ALDH1A1 1880/4885 |
| US-20210122776-A1 | COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS | FPR1, VIL1, VIP | MAPT 955/4885KDM4E 4317/4885ALDH1A1 526/4885 |
| US-10738070-B2 | Mannose-derived antagonists of FimH useful for treating disease | MAN2B2, MAN2A1, MANBA | MAPT 2578/4885KDM4E 4648/4885ALDH1A1 1880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.