Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 9/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14061988 | 0.81 | DGAT1 (0.50) | MAPTALDH1A1LMNAPKMHTT | |
| SCHEMBL14061881 | 0.80 | ALDH1A1 (0.43) | MAPTALDH1A1LMNAPKMHTT | |
| SCHEMBL14061748 | 0.80 | DGAT1 (0.54) | MAPTALDH1A1LMNAPKMHTT | |
| SCHEMBL14061838 | 0.78 | ALDH1A1 (0.42) | MAPTALDH1A1LMNAPKMHTT | |
| SCHEMBL14061937 | 0.76 | DGAT1 (0.53) | MAPTALDH1A1LMNAPKMHTT | |
| SCHEMBL14137094 | 0.76 | DGAT1 (0.55) | DGAT1 | |
| SCHEMBL17211801 | 0.74 | SMN1; SMN2 (0.43) | MAPTALDH1A1LMNAPKMHTT | |
| SCHEMBL14061930 | 0.73 | DGAT1 (0.48) | DGAT1 | |
| SCHEMBL14061955 | 0.73 | DGAT1 (0.45) | MAPTALDH1A1LMNAPKMHTT | |
| SCHEMBL14137109 | 0.72 | DGAT1 (0.49) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2723332-B1 | NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2016-03-02 | — | — | EP | disclosed |
| EP-2723332-A1 | NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2014-04-30 | — | — | EP | disclosed |
| WO-2012162127-A1 | NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2012-11-29 | — | — | WO | disclosed |