Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 18/20 | 0.49 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14061881 | 0.85 | ALDH1A1 (0.43) | DGAT1 | |
| SCHEMBL14137104 | 0.83 | DGAT1 (0.50) | DGAT1 | |
| SCHEMBL14061930 | 0.83 | DGAT1 (0.48) | DGAT1 | |
| SCHEMBL14060558 | 0.76 | DGAT1 (0.74) | DGAT1 | |
| SCHEMBL14061988 | 0.75 | DGAT1 (0.50) | DGAT1 | |
| SCHEMBL14061748 | 0.75 | DGAT1 (0.54) | DGAT1 | |
| SCHEMBL14137094 | 0.75 | DGAT1 (0.55) | DGAT1 | |
| SCHEMBL14061838 | 0.73 | ALDH1A1 (0.42) | DGAT1 | |
| SCHEMBL14061637 | 0.73 | DGAT1 (0.39) | DGAT1 | |
| SCHEMBL14062073 | 0.72 | MAPT (0.43) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012162127-A1 | NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2012-11-29 | — | — | WO | disclosed |