Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR132 | Q9UNW8 | 7/20 | 0.56 |
| ▸ | CMKLR2 | P46091 | 1/20 | 0.56 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | ECE1 | P42892 | 1/20 | 0.55 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | MMP1 | P03956 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | MMP3 | P08254 | 1/20 | 0.49 |
| ▸ | MMP7 | P09237 | 1/20 | 0.49 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.49 |
| ▸ | CTRC | Q99895 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leucine SCHEMBL3816604 | 0.97 | GPR132 (0.53) | GPR132CMKLR2CMKLR1LMNAECE1 | |
| SCHEMBL234157 | 0.89 | PSMB5 (0.54) | GPR132CMKLR2CMKLR1LMNAECE1 | |
| SCHEMBL3497405 | 0.88 | GPR132 (0.69) | GPR132CMKLR2CMKLR1LMNAECE1 | |
| SCHEMBL30037998 | 0.88 | GPR132 (0.69) | GPR132CMKLR2CMKLR1LMNAECE1 | |
| SCHEMBL2229201 | 0.88 | GPR132 (0.69) | GPR132CMKLR2CMKLR1LMNAECE1 | |
| SCHEMBL3202113 | 0.86 | GPR132 (0.53) | GPR132CMKLR2CMKLR1LMNAECE1 | |
| Leucine SCHEMBL15689579 | 0.85 | PSMB5 (0.57) | LTA4HPSMB5 | |
| Leucine SCHEMBL1406108 | 0.84 | PSMB5 (0.66) | LTA4HPSMB5 | |
| Leucine SCHEMBL19712512 | 0.84 | PSMB5 (0.66) | LTA4HPSMB5 | |
| SCHEMBL2228194 | 0.83 | LMNA (0.57) | GPR132LMNAECE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1355910-B1 | FORMULATION OF BORONIC ACID COMPOUNDS | US OF AMERICA REPRESENTED BY THE SECRETARY DEPT OF HEALTH AND HUMAN SERVICES (US) | 2011-03-09 | — | — | EP | claimed |
| EP-0788360-B3 | BORONIC ESTER AND ACID COMPOUNDS, SYNTHESIS AND USES | MILLENNIUM PHARM INC (US) | 2009-08-12 | — | — | EP | claimed |
| EP-0788360-B1 | BORONIC ESTER AND ACID COMPOUNDS, SYNTHESIS AND USES | MILLENNIUM PHARM INC (US) | 2003-05-28 | — | — | EP | claimed |