Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR132 | Q9UNW8 | 9/20 | 0.69 |
| ▸ | ECE1 | P42892 | 1/20 | 0.68 |
| ▸ | CMKLR2 | P46091 | 1/20 | 0.68 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | CTRC | Q99895 | 1/20 | 0.60 |
| ▸ | ACE | P12821 | 2/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.58 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3497405 | 1.00 | GPR132 (0.69) | GPR132ECE1CMKLR2CMKLR1LMNA | |
| SCHEMBL2229201 | 1.00 | GPR132 (0.69) | GPR132ECE1CMKLR2CMKLR1LMNA | |
| SCHEMBL10659411 | 0.92 | GPR132 (0.72) | GPR132ECE1CMKLR2CMKLR1ACE | |
| SCHEMBL30037402 | 0.91 | GPR132 (0.61) | GPR132ECE1CMKLR2CMKLR1LMNA | |
| SCHEMBL6860313 | 0.91 | GPR132 (0.61) | GPR132ECE1CMKLR2CMKLR1LMNA | |
| SCHEMBL23489730 | 0.89 | ECE1 (0.65) | GPR132ECE1CMKLR2CMKLR1LMNA | |
| SCHEMBL7415738 | 0.88 | ECE1 (0.64) | GPR132ECE1CMKLR2CMKLR1LMNA | |
| SCHEMBL27520437 | 0.88 | ECE1 (0.64) | GPR132ECE1CMKLR2CMKLR1LMNA | |
| Leucine SCHEMBL1406326 | 0.88 | GPR132 (0.56) | GPR132ECE1CMKLR2CMKLR1LMNA | |
| SCHEMBL6860349 | 0.87 | ECE1 (0.62) | GPR132ECE1CMKLR2CMKLR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230355550-A1 | KETAMINE COMPOUNDS AND PROCESSES FOR MAKING AND USING THEM | ALTER DOMUS (US) LLC | 2023-11-09 | — | — | US | disclosed |
| US-11753378-B2 | Ketamine compounds and processes for making and using them | ZEVRA THERAPEUTICS, INC. (US) | 2023-09-12 | — | — | US | disclosed |
| US-20220348544-A1 | KETAMINE COMPOUNDS AND PROCESSES FOR MAKING AND USING THEM | ALTER DOMUS (US) LLC | 2022-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11753378-B2 | Ketamine compounds and processes for making and using them | OPRK1, GRIK3, GRIN3B | GPR132 2192/4885ECE1 1292/4885CMKLR2 2627/4885 |
| US-20230355550-A1 | KETAMINE COMPOUNDS AND PROCESSES FOR MAKING AND USING THEM | OPRK1, GRIK3, GRIN3B | GPR132 2192/4885ECE1 1292/4885CMKLR2 2627/4885 |
| US-20220348544-A1 | KETAMINE COMPOUNDS AND PROCESSES FOR MAKING AND USING THEM | OPRK1, GRIK3, GRIN3B | GPR132 2192/4885ECE1 1292/4885CMKLR2 2627/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.