Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.45 |
| ▸ | DRD2 | P14416 | 5/20 | 0.45 |
| ▸ | HTR7 | P34969 | 4/20 | 0.45 |
| ▸ | HTR6 | P50406 | 4/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.45 |
| ▸ | HTR1D | P28221 | 8/20 | 0.43 |
| ▸ | HTR1B | P28222 | 6/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1324162 | 0.87 | HTR7 (0.51) | DRD2HTR7HTR1DHTR1BCHRM2 | |
| SCHEMBL1323815 | 0.83 | KCNH2 (0.49) | HTR1ASLC6A4HTR6 | |
| SCHEMBL1322865 | 0.83 | SLC6A4 (0.54) | HTR1ASLC6A4DRD2HTR7HTR6 | |
| SCHEMBL1322812 | 0.82 | ADRA1D (0.59) | SLC6A4 | |
| SCHEMBL1322881 | 0.79 | ADRA1D (0.62) | HTR1ASLC6A4DRD2HTR7HTR6 | |
| SCHEMBL1324121 | 0.76 | SLC6A4 (0.45) | HTR1ASLC6A4HTR7HTR6 | |
| SCHEMBL1322882 | 0.76 | HTR1A (0.45) | HTR1ASLC6A4HTR7HTR2AHTR1D | |
| SCHEMBL1323781 | 0.75 | HTR1A (0.43) | HTR1ASLC6A4DRD2HTR7HTR6 | |
| SCHEMBL13955054 | 0.75 | HTR7 (0.54) | HTR1ADRD2HTR7HTR1DHTR1B | |
| SCHEMBL1406171 | 0.74 | HTR1A (0.47) | HTR1ASLC6A4DRD2HTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497279-B1 | SUBSTITUTED INDOLES AND THEIR USE AS 5HT-REUPTAKE INHIBITORS AND AS 5HT LIGANDS | MERCK PATENT GMBH (DE) | 2011-03-09 | — | — | EP | claimed |
| EP-1497279-B1 | SUBSTITUTED INDOLES AND THEIR USE AS 5HT-REUPTAKE INHIBITORS AND AS 5HT LIGANDS | MERCK PATENT GMBH (DE) | 2011-03-09 | — | — | EP | disclosed |
| EP-1497279-A2 | SUBSTITUTED INDOLES AND THEIR USE AS 5HT-REUPTAKE INHIBITORS AND AS 5HT LIGANDS | MERCK PATENT GmbH (DE) | 2005-01-19 | — | — | EP | disclosed |
| WO-2003087086-A2 | SUBSTITUTED INDOLES | MERCK PATENT GMBH (DE) | 2003-10-23 | — | — | WO | disclosed |