Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | HTR5A | P47898 | 1/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 6/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9028709 | 0.89 | HTR3E (0.44) | HTR3EHTR3BHTR3AHTR5AHTR3D | |
| SCHEMBL6022841 | 0.82 | — | — | |
| SCHEMBL29449945 | 0.82 | SLC6A2 (0.54) | HTR3EHTR3BHTR3AHTR5AHTR3D | |
| SCHEMBL1322886 | 0.82 | SLC6A2 (0.54) | HTR3EHTR3BHTR3AHTR5AHTR3D | |
| Hydrochloric Acid SCHEMBL27696929 | 0.81 | SLC6A2 (0.53) | HTR3EHTR3BHTR3AHTR5AHTR3D | |
| SCHEMBL1889871 | 0.79 | PIM1 (0.50) | HTR3EHTR3BHTR3AHTR5AHTR3D | |
| SCHEMBL13956071 | 0.78 | KDM4E (0.52) | HTR3EHTR3BHTR3AHTR5AHTR3D | |
| Hydrochloric Acid SCHEMBL15206544 | 0.78 | PIM1 (0.49) | HTR3EHTR3BHTR3AHTR5AHTR3D | |
| SCHEMBL15205714 | 0.78 | — | — | |
| SCHEMBL16354087 | 0.77 | HTR1A (0.44) | HTR1ASLC6A2SLC6A3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497279-B1 | SUBSTITUTED INDOLES AND THEIR USE AS 5HT-REUPTAKE INHIBITORS AND AS 5HT LIGANDS | MERCK PATENT GMBH (DE) | 2011-03-09 | — | — | EP | disclosed |
| EP-1633741-A1 | INDOLE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | MERCK PATENT GmbH (DE) | 2006-03-15 | — | — | EP | disclosed |
| EP-1633742-A1 | INDOLE DERIVATIVE IN THE FORM OF SEROTONIN REABSORBING INHIBITORS | MERCK PATENT GmbH (DE) | 2006-03-15 | — | — | EP | disclosed |
| EP-1497279-A2 | SUBSTITUTED INDOLES AND THEIR USE AS 5HT-REUPTAKE INHIBITORS AND AS 5HT LIGANDS | MERCK PATENT GmbH (DE) | 2005-01-19 | — | — | EP | disclosed |
| WO-2004113325-A1 | INDOLE DERIVATIVE IN THE FORM OF SEROTONIN REABSORBING INHIBITORS | MERCK PATENT GMBH (DE) | 2004-12-29 | — | — | WO | disclosed |
| WO-2004113326-A1 | INDOLE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | MERCK PATENT GMBH (DE) | 2004-12-29 | — | — | WO | disclosed |
| WO-2003087086-A2 | SUBSTITUTED INDOLES | MERCK PATENT GMBH (DE) | 2003-10-23 | — | — | WO | disclosed |