Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | NOX1 | Q9Y5S8 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16079009 | 0.85 | MAPT (0.49) | MAPTALDH1A1PKMNPC1RAB9A | |
| SCHEMBL11927569 | 0.84 | MAOA (0.52) | MAPTALDH1A1PKMNPC1RAB9A | |
| SCHEMBL14872052 | 0.79 | MAPT (0.60) | MAPTALDH1A1PKMKMT2AMAOA | |
| SCHEMBL12511895 | 0.79 | MAPT (0.60) | MAPTALDH1A1PKMRAB9AGFER | |
| SCHEMBL19657873 | 0.79 | MAPT (0.60) | MAPTALDH1A1PKMKMT2AMAOA | |
| SCHEMBL2756770 | 0.77 | NOX1 (0.50) | MAPTALDH1A1PKMNPC1RAB9A | |
| SCHEMBL16079001 | 0.77 | MAPT (0.57) | MAPTALDH1A1PKMNPC1RAB9A | |
| SCHEMBL13243303 | 0.77 | MAPT (0.57) | MAPTALDH1A1PKMNPC1RAB9A | |
| SCHEMBL627989 | 0.76 | MAOA (0.70) | MAPTNPC1RAB9AGFERPOLB | |
| SCHEMBL762766 | 0.74 | MAOA (0.68) | MAPTALDH1A1PKMNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140275169-A1 | Combination Therapies for Enhancing Protein Degradation | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-09-18 | — | — | US | disclosed |
| EP-1403698-B1 | Silver halide photographic light-sensitive material comprising a particular dye, a hydrazine derivate and a benzotriazole compound | FUJIFILM CORP (JP) | 2008-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275169-A1 | Combination Therapies for Enhancing Protein Degradation | HSPA2, HSPBP1, HSPH1 | MAPT 27/4885ALDH1A1 2288/4885PKM 3219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.