Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 7/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.55 |
| ▸ | SIK1 | P57059 | 1/20 | 0.55 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.55 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 5/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2339303 | 0.84 | FGFR1 (0.69) | TP53RAB9ASIK1SIK2SIK3 | |
| SCHEMBL2339163 | 0.83 | FGFR1 (0.67) | RAB9ASIK1SIK2SIK3HPGD | |
| SCHEMBL1381949 | 0.77 | KMT2A (0.61) | TP53TDP1MEN1KMT2ANPC1 | |
| SCHEMBL6752611 | 0.76 | FGFR1 (0.67) | RAB9ASIK1SIK2SIK3NPC1 | |
| SCHEMBL14852489 | 0.75 | FGFR1 (0.58) | TP53RAB9ATDP1MEN1KMT2A | |
| SCHEMBL13702280 | 0.74 | KMO (0.63) | RAB9ACYP2C9CYP2C19MAPK14ALDH1A1 | |
| SCHEMBL8773480 | 0.74 | ALDH1A1 (0.54) | TP53RAB9AKMT2ANPC1HPGD | |
| SCHEMBL1378814 | 0.74 | L3MBTL1 (0.58) | TP53RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL7982093 | 0.74 | NAMPT (0.57) | TP53RAB9ATDP1MEN1KMT2A | |
| SCHEMBL1381806 | 0.73 | KMT2A (0.56) | TP53TDP1MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7419995-B2 | N-substituted benzimidazoyl c-Kit inhibitors and combinatorial benzimidazole library | OSI PHARMACEUTICALS, INC. (US) | 2008-09-02 | — | — | US | disclosed |
| US-7419995-B2 | N-substituted benzimidazoyl c-Kit inhibitors and combinatorial benzimidazole library | OSI PHARMACEUTICALS, INC. (US) | 2008-09-02 | — | — | US | disclosed |