Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 5/20 | 0.37 |
| ▸ | CES1 | P23141 | 5/20 | 0.37 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.33 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27833885 | 0.81 | CNR1 (0.38) | CXCR5FFAR1CNR1CNR2L3MBTL1 | |
| SCHEMBL24017669 | 0.78 | SIGMAR1 (0.37) | CES2CES1CXCR5SIGMAR1L3MBTL1 | |
| SCHEMBL4834074 | 0.76 | ALDH1A1 (0.46) | — | |
| SCHEMBL12463310 | 0.74 | HTR2B (0.42) | SIGMAR1HTR1BHTR2BGPR65 | |
| SCHEMBL28757518 | 0.71 | CNR1 (0.38) | CXCR5FFAR1SIGMAR1CNR1CNR2 | |
| SCHEMBL1253164 | 0.71 | PDE2A (0.43) | SIGMAR1HTR1BHTR2BGPR65 | |
| SCHEMBL7003988 | 0.71 | PDE2A (0.43) | SIGMAR1HTR1BHTR2BGPR65 | |
| SCHEMBL25688660 | 0.71 | HTR1B (0.37) | SIGMAR1HTR1BHTR2BGPR65F2RL1 | |
| SCHEMBL27467123 | 0.71 | HTR1B (0.37) | CXCR5SIGMAR1HTR1BHTR2BGPR65 | |
| SCHEMBL27833886 | 0.70 | HTR1B (0.35) | SIGMAR1HTR1BHTR2BGPR65 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429607-B2 | 5-HT2B receptor antagonists | ASTERAND UK LIMITED (GB) | 2008-09-30 | — | — | US | disclosed |
| US-7429607-B2 | 5-HT2B receptor antagonists | ASTERAND UK LIMITED (GB) | 2008-09-30 | — | — | US | disclosed |
| EP-1474140-B1 | 2-OXAZOLAMINES AND THEIR USE AS 5-HT2B RECEPTOR ANTAGONISTS | ASTERAND UK LTD (GB) | 2007-11-21 | — | — | EP | disclosed |