SCHEMBL140666

SCHEMBL140666

COC(=O)c1ccc(N)c(O)c1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 3/20 0.69
CA1 P00915 3/20 0.69
CA2 P00918 3/20 0.69
CA7 P43166 3/20 0.69
CA9 Q16790 3/20 0.69
CA14 Q9ULX7 3/20 0.69
XDH P47989 2/20 0.69
KDM4E B2RXH2 8/20 0.62
MAPT P10636 7/20 0.62
ALDH1A1 P00352 6/20 0.62
HPGD P15428 6/20 0.62
GAA P10253 5/20 0.62
HSD17B10 Q99714 3/20 0.62
GLA P06280 1/20 0.62
CASP1 P29466 1/20 0.62
CASP7 P55210 1/20 0.62
ATM Q13315 1/20 0.62
LMNA P02545 4/20 0.57
L3MBTL1 Q9Y468 3/20 0.57
TDP1 Q9NUW8 2/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29433281 1.00 CA12 (0.69) CA12CA1CA2CA7CA9
Hydrochloric Acid SCHEMBL2972630 0.98 CA12 (0.67) CA12CA1CA2CA7CA9
SCHEMBL3944216 0.85 CA12 (0.51) CA12CA1CA2CA7CA9
SCHEMBL29357340 0.85 CA12 (0.69) CA12CA1CA2CA7CA9
SCHEMBL24412 0.85 CA12 (0.69) CA12CA1CA2CA7CA9
SCHEMBL29375113 0.84 KDM4E (0.72) CA12CA1CA2CA7CA9
SCHEMBL192100 0.84 KDM4E (0.72) CA12CA1CA2CA7CA9
Hydrochloric Acid SCHEMBL31119219 0.83 CA12 (0.67) CA12CA1CA2CA7CA9
Hydrochloric Acid SCHEMBL945972 0.83 CA12 (0.67) CA12CA1CA2CA7CA9
Hydrochloric Acid SCHEMBL1223871 0.82 KDM4E (0.70) CA12CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 896 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116730657-B Cold patch asphalt mixture and preparation method thereof 芜湖城瑞路桥建设有限公司 2024-07-12 CN claimed
CN-116730657-A Cold patch asphalt mixture and preparation method thereof 芜湖城瑞路桥建设有限公司 2023-09-12 CN claimed
EP-1091745-B1 TREATMENT OF HYPERPROLIFERATIVE DISORDERS CHILDREN S HOSPITAL LOS ANGELE (US) 2008-10-01 EP claimed
US-20060110743-A1 Drug evolution: drug design at hot spots KONISHI YASUO 2006-05-25 US claimed
WO-2002095393-A2 DRUG EVOLUTION: DRUG DESIGN AT HOT SPOTS NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2002-11-28 WO claimed
JP-3042638-A None JP disclosed
US-12612412-B2 Antiviral heterocyclic compounds ENANTA PHARMACEUTICALS, INC. (US) 2026-04-28 US disclosed
US-20260098032-A1 METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION PMV PHARMACEUTICALS INC (US) 2026-04-09 US disclosed
US-12577217-B2 15-PGDH inhibitor KYORIN PHARMACEUTICAL CO., LTD. (JP) 2026-03-17 US disclosed
US-12570620-B2 Covalent inhibitors of creatine kinase (CK) and uses thereof for treating and preventing cancer DANA-FARBER CANCER INSTITUTE, INC. (US) 2026-03-10 US disclosed
CN-121574765-A Lubricating grease composition for roller bearing and preparation method thereof 廊坊市兰春润滑脂有限公司 2026-02-27 CN disclosed
EP-4688751-A1 ANTIVIRAL HETEROCYCLIC COMPOUNDS Enanta Pharmaceuticals, Inc. (US) 2026-02-11 EP disclosed
WO-1991009842-A1 ELECTRO-OPTICAL MATERIALS AND LIGHT MODULATOR DEVICES CONTAINING SAME ALLIED-SIGNAL INC. (US) 1991-07-11 WO disclosed
JP-H0342638-A ORGANIC NONLINEAR OPTICAL MATERIAL TORAY IND INC 1991-02-22 JP disclosed
US-4920140-A Skin disorders CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. (FR) 1990-04-24 US disclosed
US-4740519-A Benzo (b) thiophene carboxylate derivatives and pharmaceutical compositions CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. (FR) 1988-04-26 US disclosed
US-4190594-A ABSORBERS OF ULTRAVIOLET RADIATION JOHNSON & JOHNSON (US) 1980-02-26 US disclosed
US-4150046-A ORGANIC PIGMENTS HOECHST AKTIENGESELLSCHAFT (DE) 1979-04-17 US disclosed
US-4110246-A OPTICAL BRIGHTENERS HOECHST AKTIENGESELLSCHAFT (DE) 1978-08-29 US disclosed
US-4108880-A ULTRAVIOLET ABSORBERS JOHNSON & JOHNSON (US) 1978-08-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12570620-B2 Covalent inhibitors of creatine kinase (CK) and uses thereof for treating and preventing cancer CSNK1A1L, CKMT1A; CKMT1B, KHK CA12 1623/4885CA1 3049/4885CA2 705/4885
US-12577217-B2 15-PGDH inhibitor PTGDR, ADH1A, ADRA1A CA12 2443/4885CA1 1410/4885CA2 1125/4885
US-12612412-B2 Antiviral heterocyclic compounds ZC3HAV1, NHERF1, HM13 CA12 1107/4885CA1 2884/4885CA2 1209/4885
US-20260098032-A1 METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION TP53, TP53BP1, MDM2 CA12 3515/4885CA1 3047/4885CA2 2753/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.