Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | DAO | P14920 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12266192 | 0.74 | MGLL (0.39) | MGLLMAPK1NPC1ALDH1A1LMNA | |
| SCHEMBL18951893 | 0.72 | PIK3CD (0.40) | MGLLMAPK1NPC1ALDH1A1LMNA | |
| SCHEMBL23266882 | 0.69 | PTGS2 (0.44) | MGLLMAPK1NPC1ALDH1A1LMNA | |
| SCHEMBL26003113 | 0.69 | MGLL (0.36) | MGLLMAPK1NPC1ALDH1A1LMNA | |
| SCHEMBL18087421 | 0.68 | MGLL (0.35) | MGLLMAPK1NPC1ALDH1A1LMNA | |
| SCHEMBL19677418 | 0.67 | PTGS2 (0.41) | MGLLMAPK1NPC1ALDH1A1LMNA | |
| SCHEMBL18347240 | 0.66 | MAPK14 (0.56) | ALDH1A1LMNASMN1; SMN2HPGDBRD4 | |
| SCHEMBL18324218 | 0.66 | GRIA2 (0.36) | MGLLMAPK1NPC1ALDH1A1LMNA | |
| SCHEMBL22971668 | 0.65 | HTR2C (0.43) | — | |
| SCHEMBL10121965 | 0.63 | MGLL (0.42) | MGLLALDH1A1LMNAMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234332-A1 | RAF KINASE INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. | 2008-09-25 | — | — | US | disclosed |
| US-20080221132-A1 | Multi-Functional Small Molecules as Anti-Proliferative Agents | CURIS, INC. | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221132-A1 | Multi-Functional Small Molecules as Anti-Proliferative Agents | HDAC1, HDAC6, HDAC5 | MGLL 3562/4885MAPK1 451/4885NPC1 3092/4885 |
| US-20080234332-A1 | RAF KINASE INHIBITORS CONTAINING A ZINC BINDING MOIETY | BRAF, RAF1, BAZ2B | MGLL 3582/4885MAPK1 248/4885NPC1 2305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.