Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALPI | P09923 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18951893 | 0.83 | PIK3CD (0.40) | GRIA2GRIN2AMGLLMAPTALDH1A1 | |
| SCHEMBL13975261 | 0.79 | DRD2 (0.39) | MEN1KMT2APDE10AMAPTALDH1A1 | |
| SCHEMBL591171 | 0.75 | MEN1 (0.36) | MEN1KMT2APDE10ACYP3A4CYP2C9 | |
| SCHEMBL22559358 | 0.75 | MEN1 (0.36) | MEN1KMT2APDE10ACYP3A4CYP2C9 | |
| SCHEMBL7952618 | 0.75 | SMN1; SMN2 (0.42) | MEN1KMT2APDE10AALDH1A1MAPK1 | |
| SCHEMBL18087421 | 0.75 | MGLL (0.35) | PTGER3MGLLMAPTALDH1A1MAPK1 | |
| SCHEMBL18468618 | 0.75 | CYP3A4 (0.37) | MEN1KMT2APDE10AMAPTALDH1A1 | |
| SCHEMBL21146530 | 0.74 | HDAC4 (0.39) | MEN1KMT2APDE10AALDH1A1CYP3A4 | |
| SCHEMBL15473327 | 0.74 | PTGDR2 (0.43) | KMT2AMGLLMAPTALDH1A1NPC1 | |
| SCHEMBL25743029 | 0.74 | PSMB5 (0.37) | GRIA2GRIN2AMGLLMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2712358-B1 | PYRROLIDINYL UREA, PYRROLIDINYL THIOUREA AND PYRROLIDINYL GUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2016-12-21 | — | — | EP | disclosed |