Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK1D | Q8IU85 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.45 |
| ▸ | GBA1 | P04062 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14625957 | 0.84 | PTPN11 (0.57) | POLBSMN1; SMN2PTPN11GBA1ALDH1A1 | |
| SCHEMBL14590423 | 0.79 | PTPN11 (0.46) | POLBPTPN11JAK2ALDH1A1MAPK1 | |
| SCHEMBL14067297 | 0.79 | LRRK2 (0.48) | LRRK2JAK2ALDH1A1CNR2 | |
| SCHEMBL14590424 | 0.79 | CNR2 (0.46) | LRRK2JAK2CNR2 | |
| SCHEMBL30751529 | 0.78 | SYK (0.56) | CAMK1DLRRK2JAK2 | |
| SCHEMBL14590419 | 0.76 | MAPT (0.59) | POLBSMN1; SMN2HTTALDH1A1MAPK1 | |
| SCHEMBL14590427 | 0.76 | ALDH1A1 (0.53) | SMN1; SMN2LRRK2JAK2ALDH1A1KDM4E | |
| Formic Acid SCHEMBL30422549 | 0.75 | PDE4B (0.50) | CAMK1DPOLBSMN1; SMN2PTPN11 | |
| SCHEMBL14590422 | 0.74 | MAPT (0.63) | POLBSMN1; SMN2HTTALDH1A1MAPK1 | |
| SCHEMBL10328117 | 0.74 | PIK3CA (0.51) | PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1325910-B1 | ALIPHATIC NITROGENOUS FIVE-MEMBERED RING COMPOUNDS | MITSUBISHI TANABE PHARMA CORP (JP) | 2008-09-17 | — | — | EP | disclosed |
| US-7160877-B2 | Aliphatic nitrogen-containing 5-membered ring compound | TANABE SEIYAKU CO., LTD. (JP) | 2007-01-09 | — | — | US | disclosed |