Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.40 |
| ▸ | KIT | P10721 | 3/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
| ▸ | MAP3K12 | Q12852 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 3/20 | 0.38 |
| ▸ | HTR1B | P28222 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4746434 | 0.77 | KIT (0.56) | PRMT5WDR77AAK1KIT | |
| SCHEMBL12112421 | 0.71 | L3MBTL1 (0.56) | S1PR1L3MBTL1MAPT | |
| SCHEMBL4743672 | 0.70 | BRD4 (0.67) | PRMT5WDR77 | |
| SCHEMBL38665653 | 0.68 | L3MBTL1 (0.65) | S1PR1L3MBTL1HTR1DKDM4EMEN1 | |
| SCHEMBL4200987 | 0.68 | MAPK8 (0.60) | PRMT5WDR77AAK1KITMAP3K12 | |
| SCHEMBL21069142 | 0.68 | PRMT5 (0.54) | PRMT5WDR77AAK1KITL3MBTL1 | |
| SCHEMBL12267104 | 0.67 | L3MBTL1 (0.67) | S1PR1L3MBTL1MAPT | |
| SCHEMBL4209183 | 0.67 | CYP11B1 (0.49) | PRMT5WDR77AAK1 | |
| SCHEMBL8457708 | 0.67 | L3MBTL1 (0.54) | S1PR1L3MBTL1HTR1DHTR1BHTR2A | |
| SCHEMBL25383956 | 0.67 | L3MBTL1 (0.42) | S1PR1L3MBTL1KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | disclosed |