Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 1/20 | 0.56 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.54 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.45 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.42 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4209183 | 0.84 | CYP11B1 (0.49) | LRRK2PRMT5WDR77AXLCDK8 | |
| SCHEMBL4199507 | 0.79 | CAMKK2 (0.61) | LRRK2PRMT5WDR77AXLCDK8 | |
| SCHEMBL4744090 | 0.79 | PLCG1 (0.47) | LRRK2PRMT5WDR77AAK1PLCG1 | |
| SCHEMBL14069155 | 0.77 | PRMT5 (0.41) | KITPRMT5WDR77AAK1 | |
| SCHEMBL13199611 | 0.75 | LRRK2 (0.51) | LRRK2PRMT5WDR77AAK1 | |
| SCHEMBL4200987 | 0.75 | MAPK8 (0.60) | KITLRRK2PRMT5WDR77AXL | |
| SCHEMBL20846157 | 0.75 | LRRK2 (0.49) | KITLRRK2AXLCDK8TNIK | |
| SCHEMBL4747127 | 0.74 | MAPK14 (0.55) | TNIK | |
| SCHEMBL21069142 | 0.74 | PRMT5 (0.54) | KITLRRK2PRMT5WDR77AXL | |
| SCHEMBL4351841 | 0.74 | CHEK1 (0.58) | LRRK2PRMT5WDR77AXLCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | claimed |
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | disclosed |