Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 12/20 | 0.46 |
| ▸ | TEK | Q02763 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 6/20 | 0.43 |
| ▸ | ESYT2 | A0FGR8 | 1/20 | 0.43 |
| ▸ | PLEKHG3 | A1L390 | 1/20 | 0.43 |
| ▸ | NBAS | A2RRP1 | 1/20 | 0.43 |
| ▸ | CNOT1 | A5YKK6 | 1/20 | 0.43 |
| ▸ | TBKBP1 | A7MCY6 | 1/20 | 0.43 |
| ▸ | MYO1G | B0I1T2 | 1/20 | 0.43 |
| ▸ | AGPS | O00116 | 1/20 | 0.43 |
| ▸ | MYO1F | O00160 | 1/20 | 0.43 |
| ▸ | SNAP23 | O00161 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14070272 | 0.84 | BTK (0.54) | BTKLMNANPC1RAB9ABRAF | |
| SCHEMBL14069588 | 0.84 | BTK (0.67) | BTKLMNABRAFTEKCSF1R | |
| SCHEMBL14070273 | 0.83 | BTK (0.52) | BTKLMNABRAFCSF1RKIT | |
| SCHEMBL14070075 | 0.82 | BTK (0.49) | BTKLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14070288 | 0.82 | BTK (0.55) | BTKLMNABRAFTEKCSF1R | |
| SCHEMBL14070061 | 0.82 | KDR (0.52) | BTKNPC1RAB9ABRAFCSF1R | |
| SCHEMBL14070268 | 0.82 | BTK (0.51) | BTKNPC1RAB9ASMN1; SMN2BRAF | |
| SCHEMBL14070274 | 0.81 | BRAF (0.57) | BTKBRAFCSF1RRAF1 | |
| SCHEMBL14069739 | 0.81 | BTK (0.44) | BTKSYKMAPKAPK2MAPK14 | |
| SCHEMBL4786461 | 0.78 | BRAF (0.62) | BTKBRAFCSF1RRAF1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008112695-A2 | PYRAZOLO [3,4-D] PYRIMIDINES AND 1, 2, 5, 6-TETRAAZA- AS- INDACENES AS PROTEIN KINASE INHIBITORS FOR CANCER TREATMENT | IRM LLC (BM) | 2008-09-18 | — | — | WO | disclosed |