Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 15/20 | 0.57 |
| ▸ | BTK | Q06187 | 3/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14069588 | 0.85 | BTK (0.67) | BRAFBTKRAF1CSF1R | |
| SCHEMBL14070273 | 0.84 | BTK (0.52) | BRAFBTKRAF1CSF1R | |
| SCHEMBL14069849 | 0.84 | EGFR (0.61) | BRAFBTK | |
| SCHEMBL14069850 | 0.83 | KIT (0.61) | BRAFBTKCSF1R | |
| SCHEMBL14070288 | 0.83 | BTK (0.55) | BRAFBTKRAF1CSF1R | |
| SCHEMBL14069569 | 0.83 | BRAF (0.53) | BRAFBTKRAF1 | |
| SCHEMBL14070272 | 0.82 | BTK (0.54) | BRAFBTKRAF1CSF1R | |
| SCHEMBL14070059 | 0.81 | BTK (0.49) | BRAFBTKRAF1CSF1R | |
| SCHEMBL14070268 | 0.80 | BTK (0.51) | BRAFBTKCSF1R | |
| SCHEMBL20558521 | 0.79 | BTK (0.67) | BRAFBTKRAF1CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008112695-A2 | PYRAZOLO [3,4-D] PYRIMIDINES AND 1, 2, 5, 6-TETRAAZA- AS- INDACENES AS PROTEIN KINASE INHIBITORS FOR CANCER TREATMENT | IRM LLC (BM) | 2008-09-18 | — | — | WO | disclosed |