Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 3/20 | 0.40 |
| ▸ | BRAF | P15056 | 3/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | SREBF2 | Q12772 | 3/20 | 0.40 |
| ▸ | SREBF1 | P36956 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29371951 | 0.79 | PDGFRB (0.48) | WNT3AMAP4K4PDGFRBPDGFRASREBF2 | |
| SCHEMBL26317752 | 0.78 | FGFR2 (0.56) | DOT1LMAP4K4RAF1BRAFPDGFRB | |
| SCHEMBL31555358 | 0.77 | CYP1A2 (0.52) | MAP4K4SREBF2SREBF1PIK3CA | |
| SCHEMBL14063624 | 0.77 | FGFR2 (0.45) | DOT1LRAF1BRAFPDGFRBPDGFRA | |
| SCHEMBL14072379 | 0.74 | LOX (0.47) | MAP4K4SREBF2SREBF1PIK3CA | |
| SCHEMBL14072815 | 0.73 | ACVR1 (0.57) | PIK3CD | |
| SCHEMBL10272931 | 0.73 | CYP2A6 (0.50) | PDGFRBPDGFRASREBF2SREBF1PIK3CD | |
| SCHEMBL19723173 | 0.71 | HTR1A (0.53) | DOT1LPDGFRBPDGFRAHTR1AADRA1D | |
| SCHEMBL28581110 | 0.71 | LMNA (0.61) | PDGFRBPDGFRAHTR1AADRA1DADRA1A | |
| SCHEMBL7515433 | 0.70 | SREBF1 (0.46) | MAP4K4SREBF2SREBF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429604-B2 | Six-membered heterocycles useful as serine protease inhibitors | BRISTOL MYERS SQUIBB COMPANY (US) | 2008-09-30 | — | — | US | disclosed |