Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 3/20 | 0.45 |
| ▸ | GAK | O14976 | 1/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.41 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.41 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 3/20 | 0.40 |
| ▸ | BRAF | P15056 | 3/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26317752 | 0.78 | FGFR2 (0.56) | FGFR2DOT1LRAF1BRAFPDGFRB | |
| SCHEMBL14072850 | 0.77 | WNT3A (0.41) | DOT1LRAF1BRAFPDGFRBPDGFRA | |
| SCHEMBL14063596 | 0.74 | ACVR2A (0.43) | — | |
| SCHEMBL19723173 | 0.74 | HTR1A (0.53) | DOT1LPDGFRBPDGFRA | |
| SCHEMBL14063581 | 0.73 | PARP1 (0.56) | — | |
| SCHEMBL10220722 | 0.73 | CYP2A6 (0.50) | PDGFRBPDGFRAPIK3CA | |
| SCHEMBL28581110 | 0.71 | LMNA (0.61) | FGFR2GAKRIPK2COQ8ANLK | |
| SCHEMBL14063615 | 0.70 | KIF11 (0.53) | MAPTLMNAPIK3CA | |
| SCHEMBL24010756 | 0.69 | DOT1L (0.48) | FGFR2DOT1LPDGFRBPDGFRAKDM4E | |
| SCHEMBL14063628 | 0.69 | DYRK1A (0.42) | CYP3A4HPGDKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429604-B2 | Six-membered heterocycles useful as serine protease inhibitors | BRISTOL MYERS SQUIBB COMPANY (US) | 2008-09-30 | — | — | US | disclosed |