Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 8/20 | 0.72 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.60 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.54 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.53 |
| ▸ | RARB | P10826 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11319357 | 0.87 | PLK1 (0.66) | PLK1NR1H4TP53TSHRPLA2G4B | |
| SCHEMBL14075254 | 0.86 | PLK1 (0.75) | PLK1NR1H4PLK3TP53TSHR | |
| SCHEMBL11193309 | 0.83 | PLK1 (0.60) | PLK1NR1H4TP53LMNAPOLB | |
| SCHEMBL9713903 | 0.79 | PLK1 (0.74) | PLK1NR1H4TP53TSHRPLA2G4B | |
| SCHEMBL8027782 | 0.79 | PLK1 (0.93) | PLK1NR1H4PLK3TP53TSHR | |
| SCHEMBL11146339 | 0.79 | PLK1 (0.55) | PLK1NR1H4TP53RARBLMNA | |
| SCHEMBL14075266 | 0.78 | PLK1 (0.78) | PLK1NR1H4PLK3TP53TSHR | |
| SCHEMBL11146334 | 0.77 | MAPT (0.54) | PLK1NR1H4TP53LMNAPOLB | |
| SCHEMBL9306724 | 0.77 | NR1H4 (0.77) | PLK1NR1H4TP53TSHRPLA2G4B | |
| SCHEMBL9621389 | 0.77 | MAPT (0.68) | PLK1NR1H4TP53LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429677-B2 | Small molecule entry inhibitors | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2008-09-30 | — | — | US | disclosed |
| US-7429677-B2 | Small molecule entry inhibitors | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2008-09-30 | — | — | US | disclosed |