Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 4/20 | 0.65 |
| ▸ | DHODH | Q02127 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.64 |
| ▸ | MEN1 | O00255 | 4/20 | 0.64 |
| ▸ | TP53 | P04637 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 3/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | F2 | P00734 | 1/20 | 0.59 |
| ▸ | F10 | P00742 | 1/20 | 0.59 |
| ▸ | PLG | P00747 | 1/20 | 0.59 |
| ▸ | PLAU | P00749 | 1/20 | 0.59 |
| ▸ | PLAT | P00750 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14087662 | 0.90 | DHODH (0.69) | DHODHKMT2AMEN1KDM4EPOLB | |
| SCHEMBL14855907 | 0.90 | DHODH (0.73) | DHODHKMT2AMEN1KDM4EPOLB | |
| SCHEMBL11405554 | 0.88 | LMNA (0.76) | LMNADHODHKMT2AMEN1TP53 | |
| SCHEMBL4669122 | 0.88 | LMNA (0.76) | LMNADHODHKMT2AMEN1TP53 | |
| SCHEMBL22191397 | 0.85 | DHODH (0.68) | DHODHKMT2AMEN1KDM4EPOLB | |
| SCHEMBL14075242 | 0.85 | DHODH (0.88) | DHODHKMT2AMEN1KDM4EPOLB | |
| SCHEMBL8194070 | 0.85 | MEN1 (0.77) | ALOX15LMNAKMT2AMEN1TP53 | |
| SCHEMBL2028671 | 0.84 | DHODH (0.86) | DHODHKMT2AMEN1NPC1RAB9A | |
| SCHEMBL22191760 | 0.84 | KMT2A (0.76) | DHODHKMT2AMEN1KDM4EHPGD | |
| SCHEMBL24312443 | 0.84 | NPC1 (0.69) | DHODHKMT2AMEN1HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429677-B2 | Small molecule entry inhibitors | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2008-09-30 | — | — | US | disclosed |