Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.58 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.56 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.54 |
| ▸ | PPARA | Q07869 | 1/20 | 0.54 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5931215 | 0.94 | DHODH (0.76) | DHODHMEN1KMT2APKMKCNK2 | |
| SCHEMBL14855907 | 0.92 | DHODH (0.73) | DHODHMEN1KMT2APKMPOLB | |
| SCHEMBL14087662 | 0.89 | DHODH (0.69) | DHODHMEN1KMT2APKMPOLB | |
| SCHEMBL14075242 | 0.88 | DHODH (0.88) | DHODHMEN1KMT2APKMPOLB | |
| SCHEMBL13870852 | 0.88 | KMT2A (0.69) | DHODHMEN1KMT2APKMPOLB | |
| SCHEMBL2028671 | 0.87 | DHODH (0.86) | DHODHMEN1KMT2APKMKCNK2 | |
| SCHEMBL24312443 | 0.87 | NPC1 (0.69) | DHODHMEN1KMT2APKMPOLB | |
| SCHEMBL13870857 | 0.87 | DHODH (0.67) | DHODHMEN1KMT2APKMPOLB | |
| SCHEMBL14075282 | 0.85 | ALOX15 (0.66) | DHODHMEN1KMT2APKMPOLB | |
| SCHEMBL22191760 | 0.84 | KMT2A (0.76) | DHODHMEN1KMT2APKMPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220073470-A1 | INHIBITORS OF CGAS ACTIVITY AS THERAPEUTIC AGENTS | BELLBROOK LABS, LLC | 2022-03-10 | — | — | US | claimed |
| EP-3906229-A1 | INHIBITORS OF CGAS ACTIVITY AS THERAPEUTIC AGENTS | Bellbrook Labs, Llc (US) | 2021-11-10 | — | — | EP | claimed |
| CN-113286785-A | Inhibitors of cGAS activity as therapeutic agents | 贝尔布鲁克实验室有限责任公司 | 2021-08-20 | — | — | CN | claimed |
| WO-2020142735-A1 | INHIBITORS OF CGAS ACTIVITY AS THERAPEUTIC AGENTS | BellBrook Labs (US) | 2020-07-09 | — | — | WO | claimed |
| US-20220073470-A1 | INHIBITORS OF CGAS ACTIVITY AS THERAPEUTIC AGENTS | BELLBROOK LABS, LLC | 2022-03-10 | — | — | US | disclosed |
| US-20220073470-A1 | INHIBITORS OF CGAS ACTIVITY AS THERAPEUTIC AGENTS | BELLBROOK LABS, LLC | 2022-03-10 | — | — | US | disclosed |
| WO-2020142735-A1 | INHIBITORS OF CGAS ACTIVITY AS THERAPEUTIC AGENTS | BellBrook Labs (US) | 2020-07-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220073470-A1 | INHIBITORS OF CGAS ACTIVITY AS THERAPEUTIC AGENTS | CGAS, STING1, IRF3 | DHODH 2912/4885MEN1 3914/4885KMT2A 3981/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.