Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.68 |
| ▸ | RAB9A | P51151 | 5/20 | 0.68 |
| ▸ | MAPT | P10636 | 5/20 | 0.68 |
| ▸ | HPGD | P15428 | 5/20 | 0.68 |
| ▸ | NPC1 | O15118 | 5/20 | 0.68 |
| ▸ | TP53 | P04637 | 4/20 | 0.68 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | HTT | P42858 | 3/20 | 0.68 |
| ▸ | GFER | P55789 | 3/20 | 0.68 |
| ▸ | PKM | P14618 | 2/20 | 0.68 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14075990 | 0.85 | ALDH1A1 (0.65) | ALDH1A1KDM4EHSD17B10RAB9AMAPT | |
| SCHEMBL14364730 | 0.85 | ALDH1A1 (0.65) | ALDH1A1KDM4EHSD17B10RAB9AMAPT | |
| SCHEMBL9755122 | 0.81 | ALDH1A1 (1.00) | ALDH1A1KDM4EHSD17B10RAB9AMAPT | |
| SCHEMBL10030014 | 0.81 | NLRP3 (0.61) | ALDH1A1KDM4EHSD17B10RAB9AMAPT | |
| SCHEMBL1104834 | 0.81 | NLRP3 (0.65) | ALDH1A1KDM4EHSD17B10RAB9AMAPT | |
| SCHEMBL10249140 | 0.80 | MEN1 (0.66) | ALDH1A1KDM4EHSD17B10RAB9AMAPT | |
| SCHEMBL15080534 | 0.79 | CA12 (0.49) | ALDH1A1KDM4EHSD17B10RAB9AMAPT | |
| SCHEMBL30425393 | 0.77 | CA1 (0.64) | ALDH1A1RAB9APKMCA12CA1 | |
| SCHEMBL17149164 | 0.76 | HDAC1 (0.49) | ALDH1A1KDM4EHSD17B10RAB9AMAPT | |
| SCHEMBL10248879 | 0.76 | CA1 (0.49) | ALDH1A1KDM4EHSD17B10RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE44354-E1 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-07-09 | — | — | US | disclosed |
| US-RE44338-E1 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-07-02 | — | — | US | disclosed |
| US-7425318-B2 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2008-09-16 | — | — | US | disclosed |
| US-20070254889-A1 | Compounds and methods useful for rescuing cells from beta-amyloid toxicity and treatment of Alzheimer's disease | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254889-A1 | Compounds and methods useful for rescuing cells from beta-amyloid toxicity and treatment of Alzheimer's disease | APP, BACE1, IAPP | ALDH1A1 1209/4885KDM4E 1627/4885HSD17B10 1585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.