Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NAAA | Q02083 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.41 |
| ▸ | CES2 | O00748 | 3/20 | 0.41 |
| ▸ | CES1 | P23141 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.39 |
| ▸ | CTSG | P08311 | 2/20 | 0.39 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.39 |
| ▸ | CMA1 | P23946 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7560819 | 0.79 | SMN1; SMN2 (0.48) | SMN1; SMN2TSHRLMNATDP1 | |
| SCHEMBL10333091 | 0.73 | ALDH1A1 (0.52) | SMN1; SMN2TSHRLMNATDP1 | |
| SCHEMBL5797662 | 0.73 | SMN1; SMN2 (0.72) | SMN1; SMN2TSHRHTTLMNAPOLB | |
| SCHEMBL6703692 | 0.73 | SMN1; SMN2 (0.72) | SMN1; SMN2TSHRHTTLMNAPOLB | |
| SCHEMBL6025442 | 0.72 | GAA (0.57) | SMN1; SMN2CES2CES1TSHRLMNA | |
| SCHEMBL6025444 | 0.72 | GAA (0.57) | SMN1; SMN2CES2CES1TSHRLMNA | |
| SCHEMBL6157370 | 0.72 | GAA (0.57) | SMN1; SMN2CES2CES1TSHRLMNA | |
| SCHEMBL7564185 | 0.72 | SMN1; SMN2 (0.47) | SMN1; SMN2CES2CES1TSHRPRSS1 | |
| SCHEMBL28574555 | 0.72 | SMN1; SMN2 (0.50) | SMN1; SMN2CES2CES1TSHRHTT | |
| SCHEMBL21884118 | 0.71 | TSHR (0.50) | SMN1; SMN2CES2CES1TSHRPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7425552-B2 | Antiviral agent especially to treat hepatitis C virus infections; 5-Hydroxy-4-(7-methoxy-1,1-dioxo-1,2-dihydro-1 lambda 6-benzo[1,2,4]thiadiazin-3-yl)-2-(3-methyl-butyl)-6-thiophen-2-yl-2H-py-ridazin-3-one; side effects reduction | ANADYS PHARMACEUTICALS, INC. (US) | 2008-09-16 | — | — | US | disclosed |
| US-7425552-B2 | Antiviral agent especially to treat hepatitis C virus infections; 5-Hydroxy-4-(7-methoxy-1,1-dioxo-1,2-dihydro-1 lambda 6-benzo[1,2,4]thiadiazin-3-yl)-2-(3-methyl-butyl)-6-thiophen-2-yl-2H-py-ridazin-3-one; side effects reduction | ANADYS PHARMACEUTICALS, INC. (US) | 2008-09-16 | — | — | US | disclosed |