Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | PLEC | Q15149 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7425210 | 0.73 | HCAR2 (0.46) | HCAR2HCAR3MEN1KMT2AKDM4E | |
| SCHEMBL151395 | 0.72 | HCAR2 (0.43) | HCAR2HCAR3MEN1KMT2AKDM4E | |
| SCHEMBL170375 | 0.69 | — | — | |
| SCHEMBL16615908 | 0.68 | HCAR2 (0.40) | HCAR2HCAR3MEN1KMT2AKDM4E | |
| SCHEMBL3689862 | 0.68 | GPR84 (0.41) | HCAR2HCAR3POLBKDM4ELMNA | |
| SCHEMBL24498878 | 0.67 | NPC1 (0.42) | POLBKDM4EHTTL3MBTL1NPC1 | |
| Water SCHEMBL2643978 | 0.67 | HCAR2 (0.41) | HCAR2HCAR3KDM4ELMNAL3MBTL1 | |
| SCHEMBL14895110 | 0.67 | MEN1 (0.42) | MEN1KMT2APOLBKDM4ENPC1 | |
| Hydrochloric Acid SCHEMBL16598199 | 0.67 | HCAR2 (0.39) | HCAR2HCAR3MEN1KMT2AKDM4E | |
| SCHEMBL87944 | 0.66 | ALOX15 (0.41) | HCAR2KDM4ELMNAL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836206-B1 | AZOLOPYRIMIDINE-BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV AND METHODS | BRISTOL MYERS SQUIBB CO (US) | 2011-03-09 | — | — | EP | disclosed |