SCHEMBL7425210

SCHEMBL7425210

CCCc1nc(C(=O)O)c[nH]1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 7/20 0.46
HCAR3 P49019 2/20 0.40
KDM4E B2RXH2 3/20 0.37
ALOX15 P16050 3/20 0.37
TSHR P16473 3/20 0.37
TDP1 Q9NUW8 2/20 0.37
HIF1A Q16665 2/20 0.37
MEN1 O00255 1/20 0.37
ALDH1A1 P00352 1/20 0.37
LMNA P02545 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
MAPT P10636 1/20 0.37
PKM P14618 1/20 0.37
NFKB1 P19838 1/20 0.37
THPO P40225 1/20 0.37
BLM P54132 1/20 0.37
PMP22 Q01453 1/20 0.37
KMT2A Q03164 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1082482 0.88 HCAR2 (0.50) HCAR2HCAR3KDM4EALOX15TSHR
SCHEMBL6335389 0.85 HCAR2 (0.35) HCAR2HCAR3KDM4EALOX15TSHR
SCHEMBL151395 0.85 HCAR2 (0.43) HCAR2HCAR3KDM4EALOX15TSHR
SCHEMBL11119674 0.81 HTR7 (0.36) HCAR2HCAR3KDM4EALOX15TSHR
SCHEMBL28230958 0.80 L3MBTL1 (0.41) ALDH1A1KMT2AL3MBTL1
SCHEMBL3689833 0.79 HCAR2 (0.41) HCAR2KDM4EALOX15TSHRTDP1
SCHEMBL948426 0.77 RNASEH1 (0.49) HCAR2DAO
SCHEMBL2173060 0.77 ALOX15 (0.35) HCAR2KDM4EALOX15TSHRTDP1
SCHEMBL5732065 0.77 ALOX15 (0.35) HCAR2KDM4EALOX15TSHRTDP1
SCHEMBL30088569 0.77 HCAR2 (0.41) HCAR2HCAR3KDM4EALOX15TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2846788-A1 USE OF COMPOUNDS FOR THE TREATMENT OF PAIN Akron Molecules AG (AT) 2015-03-18 EP disclosed
WO-2013167743-A1 USE OF COMPOUNDS FOR THE TREATMENT OF PAIN AKRON MOLECULES GMBH (AT) 2013-11-14 WO disclosed
EP-0986562-A1 SUBSTITUTED 1,2,4-TRIAZOLO 3,4-A]PHTHALAZINE DERIVATIVES AS GABA ALPHA 5 LIGANDS MERCK SHARP & DOHME LTD. (GB) 2000-03-22 EP disclosed
WO-1998050385-A1 SUBSTITUTED 1,2,4-TRIAZOLO[3,4-a]PHTHALAZINE DERIVATIVES AS GABA ALPHA 5 LIGANDS MERCK SHARP & DOHME LIMITED (GB) 1998-11-12 WO disclosed