Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 2/20 | 0.56 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.56 |
| ▸ | ALPG | P10696 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14079168 | 0.80 | P2RX7 (0.56) | ALDH1A1MAPK1HIF1AP2RX7ERCC5 | |
| SCHEMBL29707648 | 0.79 | ALDH1A1 (0.61) | PLAAALPGALDH1A1MAPK1HIF1A | |
| SCHEMBL14079164 | 0.76 | P2RX7 (0.52) | ALDH1A1MAPK1HIF1AP2RX7POLB | |
| SCHEMBL2454118 | 0.74 | CA12 (0.60) | PLAAALPGALDH1A1MAPK1HIF1A | |
| SCHEMBL14079167 | 0.73 | ALPL (0.54) | ALPLPLAAALPGALDH1A1MAPK1 | |
| SCHEMBL4969959 | 0.73 | ALPL (0.65) | ALPLPLAAALPGPOLBKMT2A | |
| Hydrochloric Acid SCHEMBL9996121 | 0.72 | CA12 (0.59) | PLAAALPGALDH1A1MAPK1HIF1A | |
| SCHEMBL29712843 | 0.71 | ALDH1A1 (0.69) | ALDH1A1MAPK1HIF1APOLBERCC5 | |
| SCHEMBL1144066 | 0.71 | ALDH1A1 (0.69) | ALDH1A1MAPK1HIF1APOLBERCC5 | |
| SCHEMBL16411136 | 0.71 | ALDH1A1 (0.59) | ALDH1A1MAPK1HIF1AP2RX7POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7425557-B2 | Inhibitors of glycogen synthase kinase 3 | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-16 | — | — | US | disclosed |
| US-7425557-B2 | Inhibitors of glycogen synthase kinase 3 | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-16 | — | — | US | disclosed |