SCHEMBL14080068

SCHEMBL14080068

Nc1nc2cccc(Br)c2c(=O)[nH]1

nearest known ligand 0.70

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TYMS P04818 19/20 0.70
QTRT1 Q9BXR0 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6648915 0.83 TYMS (1.00) TYMS
SCHEMBL28113233 0.76 TNKS (0.61)
SCHEMBL6650317 0.76 TYMS (1.00) TYMS
SCHEMBL28279923 0.76 TNKS2 (0.58) TYMS
SCHEMBL6652802 0.74 TYMS (1.00) TYMS
SCHEMBL18340923 0.74 MASP2 (0.48) TYMSQTRT1
SCHEMBL7825873 0.73 TYMS (0.58) TYMS
SCHEMBL6653412 0.73 TYMS (1.00) TYMS
SCHEMBL1030410 0.72 TYMS (0.57) TYMSQTRT1
SCHEMBL6651319 0.72 TYMS (1.00) TYMS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018021977-A1 GLYCINE METABOLISM MODULATORS AND USES THEREOF AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2018-02-01 WO disclosed
WO-2008109181-A2 METALLOPROTEASE INHIBITORS CONTAINING A HETEROCYCLIC MOIETY ALANTOS PHARMACEUTICALS HOLDING, INC. (US) 2008-09-12 WO disclosed