Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 2/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11943320 | 0.94 | ALDH1A1 (0.42) | ALDH1A1POLBKDM4EHPGDSMN1; SMN2 | |
| SCHEMBL11943424 | 0.92 | SMO (0.44) | NPBWR1MCHR1ALDH1A1POLBKDM4E | |
| SCHEMBL14081678 | 0.89 | NPBWR1 (0.47) | NPBWR1MCHR1ALDH1A1TP53LMNA | |
| SCHEMBL11943407 | 0.87 | ALDH1A1 (0.42) | ALDH1A1POLBKDM4EHPGDSMN1; SMN2 | |
| SCHEMBL14080924 | 0.85 | NPBWR1 (0.44) | NPBWR1MCHR1ALDH1A1POLBTP53 | |
| SCHEMBL11943328 | 0.85 | MAPK14 (0.44) | ALDH1A1POLBKDM4EHPGDSMN1; SMN2 | |
| SCHEMBL14080964 | 0.85 | NPBWR1 (0.43) | NPBWR1MCHR1ALDH1A1POLBHPGD | |
| SCHEMBL11943329 | 0.84 | ALDH1A1 (0.46) | NPBWR1MCHR1ALDH1A1POLBKDM4E | |
| SCHEMBL14081537 | 0.83 | SMO (0.47) | NPBWR1MCHR1ALDH1A1POLBKDM4E | |
| SCHEMBL14081493 | 0.83 | NPBWR1 (0.44) | NPBWR1MCHR1ALDH1A1POLBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008115385-A2 | PIPERAZINE-SUBSTITUTED PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | SCHERING CORPORATION (US) | 2008-09-25 | — | — | WO | disclosed |
| WO-2008115381-A1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | SCHERING CORPORATION (US) | 2008-09-25 | — | — | WO | disclosed |