Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 4/20 | 0.68 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.68 |
| ▸ | PRKACA | P17612 | 2/20 | 0.68 |
| ▸ | PRKX | P51817 | 2/20 | 0.68 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.68 |
| ▸ | GSK3A | P49840 | 1/20 | 0.68 |
| ▸ | GSK3B | P49841 | 1/20 | 0.68 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.68 |
| ▸ | MMP13 | P45452 | 3/20 | 0.59 |
| ▸ | GRK5 | P34947 | 1/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.57 |
| ▸ | NAMPT | P43490 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14082847 | 0.92 | ROCK1 (0.55) | ROCK1ROCK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14083039 | 0.88 | HCRTR1 (0.54) | ROCK1ROCK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14082827 | 0.86 | ROCK1 (0.62) | ROCK1ROCK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14082132 | 0.85 | SMN1; SMN2 (0.65) | LMNAALDH1A1MAPT | |
| SCHEMBL14082771 | 0.85 | KMT2A (0.56) | ROCK1ROCK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14082803 | 0.85 | ROCK2 (0.62) | ROCK1ROCK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14082133 | 0.84 | TRPV1 (0.51) | ROCK1ROCK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14082848 | 0.84 | SMN1; SMN2 (0.54) | ROCK1ROCK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14082127 | 0.83 | SMN1; SMN2 (0.51) | ROCK1ROCK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14082111 | 0.83 | MAPK1 (0.67) | ROCK1ROCK2PRKACAPRKXGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080200524-A1 | Amide compounds as ion channel ligands and uses thereof | KELLY MICHAEL G | 2008-08-21 | — | — | US | disclosed |
| US-20080200524-A1 | Amide compounds as ion channel ligands and uses thereof | KELLY MICHAEL G | 2008-08-21 | — | — | US | disclosed |
| US-7338950-B2 | Amide compounds as ion channel ligands and uses thereof | RENOVIS, INC. (US) | 2008-03-04 | — | — | US | disclosed |
| US-7338950-B2 | Amide compounds as ion channel ligands and uses thereof | RENOVIS, INC. (US) | 2008-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200524-A1 | Amide compounds as ion channel ligands and uses thereof | TRPV1, TRPA1, TRPV2 | ROCK1 3978/4885ROCK2 3870/4885CYP3A4 3342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.