Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.73 |
| ▸ | KDR | P35968 | 2/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | NAMPT | P43490 | 1/20 | 0.63 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.62 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.61 |
| ▸ | ABL1 | P00519 | 1/20 | 0.61 |
| ▸ | BCR | P11274 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.60 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | TNF | P01375 | 1/20 | 0.60 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14527301 | 0.88 | MKNK1 (0.62) | EPHX2KDRNPC1RAB9ALMNA | |
| SCHEMBL14082508 | 0.88 | POLB (0.77) | EPHX2NPC1RAB9ALMNAGAA | |
| SCHEMBL3872792 | 0.87 | NAMPT (0.78) | NPC1RAB9ALMNAGAANAMPT | |
| SCHEMBL14082509 | 0.86 | CYP11B1 (0.72) | NPC1RAB9ALMNAGAANAMPT | |
| SCHEMBL5665029 | 0.86 | EPHX2 (0.76) | EPHX2NPC1RAB9ALMNANAMPT | |
| SCHEMBL27927283 | 0.85 | EPHX2 (0.87) | EPHX2NPC1RAB9ALMNAGAA | |
| SCHEMBL14082506 | 0.85 | NAMPT (0.86) | NPC1RAB9ALMNAGAANAMPT | |
| SCHEMBL14082572 | 0.84 | DEGS1 (0.72) | EPHX2KDRNPC1RAB9ALMNA | |
| SCHEMBL14082510 | 0.83 | NAMPT (0.88) | NPC1RAB9ALMNAGAANAMPT | |
| SCHEMBL14082557 | 0.82 | BRAF (0.63) | KDRNPC1RAB9ALMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080200524-A1 | Amide compounds as ion channel ligands and uses thereof | KELLY MICHAEL G | 2008-08-21 | — | — | US | disclosed |
| US-20080200524-A1 | Amide compounds as ion channel ligands and uses thereof | KELLY MICHAEL G | 2008-08-21 | — | — | US | disclosed |
| US-7338950-B2 | Amide compounds as ion channel ligands and uses thereof | RENOVIS, INC. (US) | 2008-03-04 | — | — | US | disclosed |
| US-7338950-B2 | Amide compounds as ion channel ligands and uses thereof | RENOVIS, INC. (US) | 2008-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200524-A1 | Amide compounds as ion channel ligands and uses thereof | TRPV1, TRPA1, TRPV2 | EPHX2 2900/4885KDR 2604/4885NPC1 1061/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.