Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17058070 | 0.91 | HTR6 (0.48) | HTR1ASLC6A2SLC6A4SLC6A3MAPK14 | |
| SCHEMBL17058573 | 0.84 | GAA (0.48) | RAB9ANPC1SMN1; SMN2KMT2ALMNA | |
| SCHEMBL11943546 | 0.83 | MAPT (0.45) | RAB9ANPC1SMN1; SMN2KMT2ALMNA | |
| SCHEMBL11944525 | 0.83 | ALDH1A1 (0.65) | MAPK14RAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL17057895 | 0.83 | RAB9A (0.44) | MAPK14RAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL17057934 | 0.82 | MAPK14 (0.47) | MAPK14RAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL17058405 | 0.82 | SMN1; SMN2 (0.43) | RAB9ANPC1HTR6SMN1; SMN2KMT2A | |
| SCHEMBL11944410 | 0.82 | MAPT (0.57) | MAPK14RAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL11944537 | 0.81 | MAPT (0.51) | MAPK14RAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL17058396 | 0.81 | SMN1; SMN2 (0.43) | RAB9ANPC1SMN1; SMN2KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |
| WO-2008115385-A2 | PIPERAZINE-SUBSTITUTED PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | SCHERING CORPORATION (US) | 2008-09-25 | — | — | WO | disclosed |