Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 1/20 | 0.53 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14083702 | 0.92 | NPC1 (0.55) | KCNQ3KCNQ2PDE4DSMN1; SMN2NPC1 | |
| SCHEMBL14083662 | 0.92 | SMN1; SMN2 (0.59) | KCNQ3KCNQ2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL14082836 | 0.92 | AURKB (0.56) | PDE4DAURKBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL14083721 | 0.88 | TRPV1 (0.50) | KCNQ3KCNQ2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL14083709 | 0.86 | SMN1; SMN2 (0.55) | KCNQ3KCNQ2SMN1; SMN2RAB9AGRM4 | |
| SCHEMBL14083098 | 0.86 | SMN1; SMN2 (0.59) | KCNQ3KCNQ2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL14083634 | 0.86 | RAB9A (0.53) | KCNQ3KCNQ2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL14083836 | 0.85 | GRM4 (0.53) | KCNQ3KCNQ2AURKBSMN1; SMN2NPC1 | |
| SCHEMBL14083883 | 0.85 | TRPV1 (0.63) | AURKBSMN1; SMN2NPC1RAB9AGRM4 | |
| SCHEMBL14083640 | 0.84 | RAB9A (0.55) | KCNQ3KCNQ2SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080200524-A1 | Amide compounds as ion channel ligands and uses thereof | KELLY MICHAEL G | 2008-08-21 | — | — | US | disclosed |
| US-20080200524-A1 | Amide compounds as ion channel ligands and uses thereof | KELLY MICHAEL G | 2008-08-21 | — | — | US | disclosed |
| US-7338950-B2 | Amide compounds as ion channel ligands and uses thereof | RENOVIS, INC. (US) | 2008-03-04 | — | — | US | disclosed |
| US-7338950-B2 | Amide compounds as ion channel ligands and uses thereof | RENOVIS, INC. (US) | 2008-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200524-A1 | Amide compounds as ion channel ligands and uses thereof | TRPV1, TRPA1, TRPV2 | KCNQ3 87/4885KCNQ2 67/4885PDE4D 1812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.