Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.57 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.48 |
| ▸ | ATF1 | P18846 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | JUN | P05412 | 3/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.46 |
| ▸ | RELA | Q04206 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14083502 | 0.89 | TRPV1 (0.70) | TRPV1TMPRSS4MAPTKDM4EMAPK1 | |
| SCHEMBL14083607 | 0.86 | TRPV1 (0.58) | TRPV1TMPRSS4NFKB1ATF1MAPT | |
| SCHEMBL14083361 | 0.85 | TRPV1 (0.58) | TRPV1TMPRSS4NFKB1ATF1MAPT | |
| SCHEMBL14083217 | 0.84 | TMPRSS4 (0.52) | TRPV1TMPRSS4NFKB1ATF1MAPT | |
| SCHEMBL14084018 | 0.84 | TRPV1 (0.61) | TRPV1KDM4EMAPK1 | |
| SCHEMBL14083930 | 0.84 | GRM4 (0.62) | TRPV1MAPTKDM4ENPC1 | |
| SCHEMBL14083938 | 0.82 | TRPV1 (0.79) | TRPV1 | |
| SCHEMBL14083905 | 0.82 | RAB9A (0.60) | TRPV1MAPTKDM4ENPC1MAPK1 | |
| SCHEMBL14083762 | 0.81 | TRPV1 (0.53) | TRPV1TMPRSS4MAPTKDM4ENPC1 | |
| SCHEMBL14083333 | 0.81 | RXFP1 (0.49) | TRPV1TMPRSS4NFKB1ATF1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080200524-A1 | Amide compounds as ion channel ligands and uses thereof | KELLY MICHAEL G | 2008-08-21 | — | — | US | disclosed |
| US-20080200524-A1 | Amide compounds as ion channel ligands and uses thereof | KELLY MICHAEL G | 2008-08-21 | — | — | US | disclosed |
| US-7338950-B2 | Amide compounds as ion channel ligands and uses thereof | RENOVIS, INC. (US) | 2008-03-04 | — | — | US | disclosed |
| US-7338950-B2 | Amide compounds as ion channel ligands and uses thereof | RENOVIS, INC. (US) | 2008-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200524-A1 | Amide compounds as ion channel ligands and uses thereof | TRPV1, TRPA1, TRPV2 | TRPV1 1/4885TMPRSS4 1826/4885NFKB1 841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.