Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | BDKRB1 | P46663 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4703703 | 0.88 | MEN1 (0.46) | MEN1KMT2AALDH1A1L3MBTL1BDKRB1 | |
| SCHEMBL14084845 | 0.86 | BDKRB1 (0.57) | MEN1KMT2ABDKRB1 | |
| SCHEMBL14084817 | 0.85 | SLC6A12 (0.54) | MEN1KMT2APOLB | |
| SCHEMBL4703565 | 0.84 | CDK2 (0.53) | MEN1KMT2ABDKRB1 | |
| SCHEMBL4703545 | 0.84 | RAB9A (0.50) | MEN1KMT2AALDH1A1BDKRB1EPHX2 | |
| SCHEMBL14084821 | 0.83 | CDK2 (0.45) | MEN1KMT2ABDKRB1 | |
| SCHEMBL14084897 | 0.82 | BDKRB1 (0.60) | MEN1KMT2ABDKRB1 | |
| SCHEMBL6046008 | 0.81 | BDKRB1 (0.47) | MEN1KMT2AALDH1A1BDKRB1POLB | |
| SCHEMBL14084852 | 0.81 | DRD4 (0.49) | — | |
| SCHEMBL14084854 | 0.81 | DRD4 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7417152-B2 | 4-bromo-5-(2-chloro-benzoylamino)-1H-pyrazole-3-carboxylic acid amide derivatives and related compounds as bradykinin B1 receptor antagonists for the treatment of inflammatory diseases | ELAN PHARMACEUTICALS, INC. (US) | 2008-08-26 | — | — | US | disclosed |
| US-7417152-B2 | 4-bromo-5-(2-chloro-benzoylamino)-1H-pyrazole-3-carboxylic acid amide derivatives and related compounds as bradykinin B1 receptor antagonists for the treatment of inflammatory diseases | ELAN PHARMACEUTICALS, INC. (US) | 2008-08-26 | — | — | US | disclosed |