Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14084841 | 0.88 | MEN1 (0.52) | MEN1KMT2ABDKRB1ALDH1A1L3MBTL1 | |
| SCHEMBL4705774 | 0.87 | BDKRB1 (0.50) | MEN1KMT2ABDKRB1ALDH1A1 | |
| SCHEMBL4700955 | 0.86 | SIGMAR1 (0.48) | MEN1KMT2APOLB | |
| SCHEMBL4706230 | 0.85 | CDK2 (0.48) | MEN1KMT2ABDKRB1SMN1; SMN2 | |
| SCHEMBL4790284 | 0.85 | ITGB1 (0.49) | BDKRB1ALDH1A1EPHX2 | |
| SCHEMBL4790676 | 0.84 | CDK2 (0.42) | MEN1KMT2ABDKRB1SMN1; SMN2 | |
| SCHEMBL4700783 | 0.83 | BDKRB1 (0.53) | MEN1KMT2ABDKRB1L3MBTL1LMNA | |
| SCHEMBL4705037 | 0.83 | DRD4 (0.46) | — | |
| SCHEMBL4704842 | 0.83 | DRD4 (0.46) | — | |
| SCHEMBL4701724 | 0.83 | BDKRB1 (0.42) | MEN1KMT2ABDKRB1ALDH1A1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633348-B1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2008-10-08 | — | — | EP | claimed |