Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MDM4 | O15151 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14596251 | 0.93 | TLR2 (0.61) | TLR2KMT2AMDM4TP53 | |
| SCHEMBL14110931 | 0.93 | TLR2 (0.61) | TLR2KMT2AMDM4TP53 | |
| SCHEMBL3576902 | 0.89 | KMT2A (0.54) | TLR2KMT2AMDM4TP53PTPN1 | |
| SCHEMBL12156602 | 0.87 | PTPN1 (0.54) | TLR2KMT2APTPN1CASP3 | |
| SCHEMBL22854294 | 0.86 | TLR2 (0.54) | TLR2KMT2AMDM4TP53PTPN1 | |
| SCHEMBL2925858 | 0.85 | CTSK (0.48) | TLR2KMT2AMDM4TP53 | |
| SCHEMBL16095190 | 0.85 | MDM4 (0.58) | TLR2KMT2AMDM4TP53CASP3 | |
| SCHEMBL29398313 | 0.85 | MDM4 (0.58) | TLR2KMT2AMDM4TP53CASP3 | |
| SCHEMBL29398093 | 0.85 | MDM4 (0.58) | TLR2KMT2AMDM4TP53CASP3 | |
| SCHEMBL29541007 | 0.85 | MDM4 (0.58) | TLR2KMT2AMDM4TP53CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7417030-B2 | Indazole peptidomimetics as thrombin receptor antagonists | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2008-08-26 | — | — | US | disclosed |
| US-7417030-B2 | Indazole peptidomimetics as thrombin receptor antagonists | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2008-08-26 | — | — | US | disclosed |
| US-7183252-B2 | Indole peptidomimetics as thrombin receptor antagonists | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2007-02-27 | — | — | US | disclosed |
| US-7183252-B2 | Indole peptidomimetics as thrombin receptor antagonists | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2007-02-27 | — | — | US | disclosed |