Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | NAAA | Q02083 | 3/20 | 0.37 |
| ▸ | CASP1 | P29466 | 3/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 2/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL647101 | 0.80 | RIPK1 (0.46) | CTSLNAAACASP1 | |
| SCHEMBL1409814 | 0.78 | CASP1 (0.37) | CASP1CASP3CASP8 | |
| SCHEMBL646039 | 0.72 | CASP1 (0.50) | CASP1 | |
| SCHEMBL1409492 | 0.72 | GAA (0.35) | — | |
| SCHEMBL645174 | 0.71 | CASP1 (0.49) | CASP1 | |
| SCHEMBL645106 | 0.70 | CASP1 (0.52) | CASP1 | |
| SCHEMBL13140087 | 0.69 | RIPK1 (0.42) | CTSLNAAAGLA | |
| SCHEMBL648535 | 0.68 | XIAP (0.48) | — | |
| SCHEMBL644741 | 0.66 | SCN9A (0.47) | CTSLNAAA | |
| SCHEMBL5712951 | 0.64 | CCKBR (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295442-A2 | Inhibitors of interleukin-1beta converting enzyme | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-03-16 | — | — | EP | disclosed |