Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 13/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 10/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 9/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | FNTA | P49354 | 1/20 | 0.36 |
| ▸ | FNTB | P49356 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14092394 | 1.00 | CYP11B2 (0.45) | CYP11B2CYP19A1CYP11B1MAPK14PPARG | |
| SCHEMBL14092466 | 0.91 | CYP19A1 (0.48) | CYP11B2CYP19A1CYP11B1MAPK14FNTA | |
| SCHEMBL13803067 | 0.91 | CYP11B2 (0.48) | CYP11B2CYP19A1CYP11B1MAPK14PPARG | |
| SCHEMBL13803075 | 0.91 | CYP11B2 (0.48) | CYP11B2CYP19A1CYP11B1MAPK14PPARG | |
| SCHEMBL14092471 | 0.91 | CYP19A1 (0.48) | CYP11B2CYP19A1CYP11B1MAPK14FNTA | |
| SCHEMBL8352768 | 0.87 | CYP11B2 (0.49) | CYP11B2CYP19A1CYP11B1MAPK14PPARG | |
| SCHEMBL14092391 | 0.87 | NR3C1 (0.44) | CYP11B2CYP19A1CYP11B1NR3C2CYP1A2 | |
| SCHEMBL13802964 | 0.87 | CYP11B2 (0.49) | CYP11B2CYP19A1CYP11B1MAPK14PPARG | |
| SCHEMBL14092387 | 0.87 | NR3C1 (0.44) | CYP11B2CYP19A1CYP11B1NR3C2CYP1A2 | |
| SCHEMBL14092193 | 0.87 | PPARG (0.50) | CYP11B2CYP19A1CYP11B1PPARGNR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7411072-B2 | Tricyclic steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY (US) | 2008-08-12 | — | — | US | disclosed |
| US-7411072-B2 | Tricyclic steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY (US) | 2008-08-12 | — | — | US | disclosed |