Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.39 |
| ▸ | MIF | P14174 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.38 |
| ▸ | MDM4 | O15151 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14092391 | 1.00 | NR3C1 (0.44) | NR3C1PGRNR3C2ARALDH1A1 | |
| SCHEMBL14092466 | 0.91 | CYP19A1 (0.48) | CYP19A1CYP11B2CYP11B1KMT2ACYP1A2 | |
| SCHEMBL14092471 | 0.91 | CYP19A1 (0.48) | CYP19A1CYP11B2CYP11B1KMT2ACYP1A2 | |
| SCHEMBL14092394 | 0.87 | CYP11B2 (0.45) | NR3C2CYP19A1CYP11B2CYP11B1CYP1A2 | |
| SCHEMBL14092393 | 0.87 | CYP11B2 (0.45) | NR3C2CYP19A1CYP11B2CYP11B1CYP1A2 | |
| SCHEMBL4151124 | 0.85 | MIF (0.53) | NR3C1PGRNR3C2ARALDH1A1 | |
| SCHEMBL8353823 | 0.85 | NR3C1 (0.47) | NR3C1PGRNR3C2ARALDH1A1 | |
| SCHEMBL4174005 | 0.85 | MIF (0.53) | NR3C1PGRNR3C2ARALDH1A1 | |
| SCHEMBL4151121 | 0.85 | MIF (0.53) | NR3C1PGRNR3C2ARALDH1A1 | |
| SCHEMBL14092472 | 0.84 | CYP19A1 (0.46) | ARCYP19A1CYP11B2CYP11B1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7411072-B2 | Tricyclic steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY (US) | 2008-08-12 | — | — | US | disclosed |
| US-7411072-B2 | Tricyclic steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY (US) | 2008-08-12 | — | — | US | disclosed |