Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14095193 | 0.83 | AXL (0.41) | RAB9ANPC1MAPTKDM4ERXFP1 | |
| SCHEMBL14095195 | 0.76 | ADORA2A (0.50) | MAPTKDM4EALDH1A1HPGDL3MBTL1 | |
| SCHEMBL14104152 | 0.75 | MTOR (0.42) | RAB9ANPC1KDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL29400863 | 0.72 | MAPT (0.50) | RAB9ANPC1MAPTKDM4ERXFP1 | |
| SCHEMBL7121620 | 0.71 | PDE4A (0.55) | RAB9AMAPTHSD17B10MEN1KMT2A | |
| SCHEMBL14104063 | 0.71 | PIK3CA (0.46) | RAB9ANPC1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL14095091 | 0.70 | PDE4A (0.52) | ADORA2AADORA1PIK3CAMTORPDE4A | |
| SCHEMBL14095007 | 0.69 | TRPA1 (0.37) | MAPTRXFP1L3MBTL1 | |
| SCHEMBL29893499 | 0.69 | AXL (0.39) | RAB9ANPC1MAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL55302 | 0.69 | AXL (0.39) | RAB9ANPC1MAPTSMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008092862-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | disclosed |