Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14095494 | 0.83 | RAB9A (0.36) | AXLMKNK1MKNK2ADORA2AADORA1 | |
| SCHEMBL14095493 | 0.76 | ADORA2A (0.59) | AXLMKNK1MKNK2ADORA2AADORA1 | |
| SCHEMBL13789319 | 0.74 | AXL (0.43) | AXLMKNK1MKNK2ADORA2AADORA1 | |
| SCHEMBL29400863 | 0.73 | MAPT (0.50) | MAPTRAB9AKDM4EPOLBSMN1; SMN2 | |
| SCHEMBL3975328 | 0.73 | ALDH1A1 (0.41) | MAPTRAB9AKDM4EPOLBSMN1; SMN2 | |
| SCHEMBL2876033 | 0.72 | AXL (0.52) | AXLMKNK1MKNK2ADORA2AADORA1 | |
| SCHEMBL4744102 | 0.70 | PDE4A (0.56) | AXLMKNK1MKNK2ADORA2AADORA1 | |
| SCHEMBL13789313 | 0.70 | AXL (0.46) | AXLMKNK1MKNK2ADORA2AADORA1 | |
| SCHEMBL14103880 | 0.70 | DHPS (0.43) | AXLMKNK1MKNK2ADORA2AADORA1 | |
| SCHEMBL13789359 | 0.70 | AXL (0.39) | AXLMKNK1MKNK2ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008092862-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | disclosed |