Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 10/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MET | P08581 | 3/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14104083 | 0.82 | L3MBTL1 (0.39) | TRPA1L3MBTL1METBRD4MAPT | |
| SCHEMBL14104446 | 0.82 | TRPA1 (0.41) | TRPA1L3MBTL1METBRD4MAPT | |
| SCHEMBL14103795 | 0.80 | L3MBTL1 (0.39) | TRPA1L3MBTL1MAPTHTT | |
| SCHEMBL4574977 | 0.79 | MAPK1 (0.51) | TRPA1L3MBTL1METMAPT | |
| SCHEMBL14103756 | 0.79 | TRPA1 (0.41) | TRPA1L3MBTL1METBRD4MAPT | |
| SCHEMBL14103771 | 0.78 | TRPA1 (0.37) | TRPA1L3MBTL1METBRD4MAPT | |
| SCHEMBL14104442 | 0.78 | MET (0.38) | TRPA1L3MBTL1METBRD4MAPT | |
| SCHEMBL14103813 | 0.78 | PIK3CA (0.40) | TRPA1L3MBTL1METBRD4MAPT | |
| SCHEMBL14103885 | 0.78 | TRPA1 (0.38) | TRPA1L3MBTL1METBRD4MAP4K4 | |
| SCHEMBL14103816 | 0.78 | MTOR (0.40) | TRPA1L3MBTL1METBRD4MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008092862-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | disclosed |