Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MGAM | O43451 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | SI | P14410 | 2/20 | 0.31 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL186272 | 1.00 | ALDH1A1 (0.43) | ALDH1A1TDP1TSHRHSD17B10LMNA | |
| Propylene Glycol SCHEMBL5153420 | 0.89 | ALDH1A1 (0.50) | ALDH1A1TDP1TSHRHSD17B10LMNA | |
| Propylene Glycol SCHEMBL24226 | 0.89 | ALDH1A1 (0.56) | ALDH1A1TDP1TSHRHSD17B10LMNA | |
| Propylene Glycol SCHEMBL27714310 | 0.87 | TDP1 (0.43) | ALDH1A1TDP1TSHRHSD17B10MEN1 | |
| Propylene Glycol SCHEMBL28313165 | 0.87 | TDP1 (0.43) | ALDH1A1TDP1TSHRHSD17B10LMNA | |
| Propylene Glycol SCHEMBL28710964 | 0.86 | TDP1 (0.48) | ALDH1A1TDP1TSHRHSD17B10LMNA | |
| Propylene Glycol SCHEMBL151562 | 0.86 | TDP1 (0.48) | ALDH1A1TDP1TSHRHSD17B10LMNA | |
| Propylene Glycol SCHEMBL14685915 | 0.86 | ALDH1A1 (0.53) | ALDH1A1TDP1TSHRHSD17B10LMNA | |
| 1,3-Butanediol SCHEMBL4324455 | 0.86 | ALDH1A1 (0.39) | ALDH1A1TSHRHSD17B10LMNA | |
| Propylene Glycol SCHEMBL3820290 | 0.86 | TDP1 (0.39) | ALDH1A1TDP1TSHRHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8697583-B2 | Oxidation-promoting compositions, methods of forming oxide layers, and methods of fabricating semiconductor devices | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2014-04-15 | — | — | US | disclosed |
| US-20120058647-A1 | OXIDATION-PROMOTING COMPOSITIONS, METHODS OF FORMING OXIDE LAYERS, AND METHODS OF FABRICATING SEMICONDUCTOR DEVICES | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2012-03-08 | — | — | US | disclosed |