Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.51 |
| ▸ | MTOR | P42345 | 3/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14097625 | 0.81 | ABL1 (0.52) | PIK3CAPIK3CDABL1 | |
| SCHEMBL3659787 | 0.81 | WNT3A (0.51) | PIK3CAPIK3CDMTORPIK3CGSYK | |
| SCHEMBL14097706 | 0.80 | ABL1 (0.49) | PIK3CAABL1 | |
| SCHEMBL13436707 | 0.77 | FAAH (0.52) | PIK3CAHDAC6CNR2 | |
| SCHEMBL14097679 | 0.77 | ABL1 (0.59) | PIK3CAHDAC6ABL1 | |
| SCHEMBL14097682 | 0.76 | ABL1 (0.60) | HDAC6ABL1 | |
| SCHEMBL1444071 | 0.75 | PIK3CA (0.67) | PIK3CAPIK3CDMTORPIK3CG | |
| SCHEMBL14506599 | 0.74 | MAPK1 (0.68) | PIK3CAPIK3CD | |
| SCHEMBL14097688 | 0.74 | ABL1 (0.49) | PIK3CAHDAC6ABL1 | |
| SCHEMBL14097644 | 0.72 | ABL1 (0.56) | ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7414046-B2 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-08-19 | — | — | US | disclosed |
| US-7414046-B2 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-08-19 | — | — | US | disclosed |
| US-RE40245-E1 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-15 | — | — | US | disclosed |
| US-RE40245-E1 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-15 | — | — | US | disclosed |
| EP-1341769-B1 | BACTERIAL GYRASE INHIBITORS AND USES THEREOF | VERTEX PHARMA (US) | 2007-10-17 | — | — | EP | disclosed |